Federal government websites often end in. The site is secure. The data presented in this study are available in the article and in the Supplementary Material. The underlying mechanisms of the development of unhealthy metabolic phenotypes in obese children and adolescents remain unclear.
We aimed to screen the metabolomes of individuals with the unhealthy obesity phenotype and identify the potential metabolic pathways that could regulate various metabolic profiles of obesity in Chinese adolescents. A total of adolescents aged 11β18 years old from China were investigated using a cross-sectional study. Moreover, several metabolic pathways may be relevant in distinguishing the MHO and MUO groups, including the fatty acid biosynthesis, fatty acid elongation in mitochondria, propanoate metabolism, glyoxylate and dicarboxylate metabolism, and fatty acid metabolism pathways.
Similar results were observed for boys except for phenylalanine, tyrosine and tryptophan biosynthesis, which had a high impact [0. The identified metabolites and pathways could be efficacious for investigating the underlying mechanisms of the development of different metabolic phenotypes in obese Chinese adolescents.
Metabolic disorders, especially obesity in children and adolescents, have increased in frequency and have become a major public health issue throughout the world [ 1 ]. Similarly, the standardized prevalence of obesity in Chinese children and adolescents has increased rapidly, from 1. Studies have shown that obesity can lead to metabolic abnormalities in the body, such as elevated blood pressure, type 2 diabetes, dyslipidemia, and metabolic syndrome [ 3 ].
Recent studies have found that obese individuals do not all have the same risk of developing metabolic derangements, and individuals in the same body mass index BMI category can also have different metabolic profiles. Keihani et al. Therefore, the timely classification and identification of obese individuals with different metabolic phenotypes and the early development of cost-effective individualized prevention and intervention programs are of great significance for reducing the risk of metabolic abnormalities in obese children and adolescents.
